Study of associations of blood proteins with development of unstable atherosclerotic plaques in coronary arteries by quantitative proteomics

Aim. To study the associations of blood proteins with presence unstable atherosclerotic plaques in arteries patients coronary artery disease using quantitative proteomic analysis. Materials and methods. The included ( n = 40); average age was 58 ± 7 years. Material for serum. Protein concentrations serum samples were determined PeptiQuant Plus Proteomics Kit (Cambridge Isotope Laboratories, USA). fractions identified liquid chromatograph tandem mass spectrometer Q-TRAP 6500. Results. Mass spectrometry revealed an increased concentration proteins, such as fibrinogen, fibulin-1, complement factor H, plaques. It took place a simultaneous decrease levels α 2-antiplasmin, heparin cofactor II, coagulation XII, plasminogen, prothrombin, vitronectin, (C1, C3, C7, C9), B. differences considered significant at p < 0.05. that associated level fibulin-1 (Exp(B) 1.008; р 0.05), plasminogen (Exp(В) 0.995; 0.027), X 0.973; 0.037). Conclusion. An can be potential biomarker plaque development disease. possibility studied biomarkers requires further studies on their role this